Laboratory of Molecular Cancer Genetics

The Ciribilli laboratory investigates the molecular networks that shape breast, colon and melanoma progression. The group studies how the transcriptional repressor ETV7 creates chemoresistant and stem-like states, how shorter p53-family isoforms alter tumour behaviour, and how epithelial–mesenchymal transition and the microenvironment support angiogenesis and metastasis. Its work combines gene-expression analysis in patient material, mechanistic experiments in cancer cells, two- and three-dimensional models, molecular perturbation and translational biomarker studies to connect regulatory pathways with prognosis and treatment response.